Is your A1C accurate

Glycated Hemoglobin (A1C) is a reliable test for assessing long-term glucose control. However, several factors can affect the accuracy of the results.

Falsely Elevated HbA1c:

1. Extended RBC Lifespan: Conditions such as splenectomy or certain anemias prolong the lifespan of RBCs, allowing more time for glycation.

2. Iron Deficiency Anemia: Affects RBC turnover, leading to higher HbA1c levels.

3. Uremia: Kidney failure results in carbamylated hemoglobin, which can be mistaken for glycated hemoglobin.

4. Hyperbilirubinemia: Elevated bilirubin can interfere with some HbA1c tests.

5. Alcoholism: Chronic alcohol consumption impacts RBC metabolism, raising HbA1c.

6. Lead Poisoning: Extends RBC lifespan, resulting in higher HbA1c.

7. High-Dose Aspirin: Prolonged use can increase HbA1c levels.

8. Hemoglobin Variants (e.g., HbF): Certain variants can affect HbA1c measurement.

Falsely Reduced HbA1c:

1. Reduced RBC Lifespan: Conditions like hemolytic anemia or sickle cell disease decrease the time for glycation.

2. Recent Blood Loss/Transfusion: Introduces younger RBCs with less glycation.

3. Chronic Liver Disease: Shortens RBC lifespan, resulting in lower HbA1c.

4. Vitamin E Supplementation: High doses may decrease glycation.

5. Erythropoietin Therapy: Increases the proportion of younger RBCs, reducing HbA1c.

6. Hemoglobin Variants (e.g., HbS, HbC): Certain variants can interfere with tests, causing underestimation.

7. Pregnancy: Enhanced RBC turnover reduces HbA1c levels.

8. Hypertriglyceridemia: High triglyceride levels can interfere with tests.

Next time do not google your results. Speak to your healthcare provider and work on your A1C